It was revealed this week that Lindsey Graham, a prominent South Carolina senator, likely died of an aortic dissection. Aortic dissections are relatively uncommon compared to other cardiovascular conditions such as heart attacks — but their outcomes are often very poor.
What is aortic dissection?
The aorta is the body’s main artery. It carries oxygen- and nutrient-rich blood from the heart to the rest of the body, providing our tissues with everything they need to function properly. An aortic dissection is a tear of the innermost lining of the aorta. The inner lining, known as the intima or tunica intima, is a single layer of highly specialized cells called endothelial cells, which ensure that the blood stays in its liquid form as it flows around through the body’s blood vessels.
When damage to the endothelial layer occurs, the high-pressure blood tears through the intima layer and into the next layer, the media — literally “dissecting” a pathway into the outer layers of the aorta. If not diagnosed and treated, this can lead to complete failure of the aorta wall and blood escaping out of the vessel and into neighboring structures and tissues. This stretches the aorta and changes its biomechanical function, which can further contribute to the disease process. As blood is diverted into the tear, it can reduce flow to downstream organs — in some instances completely preventing supply to some of them. The tear also changes the flow of blood through the vessel, which can cause further damage to the specialized endothelial lining cells.
How common are aortic dissections?
In the U.S. and U.K., aortic dissections affect approximately three to four people per 100,000. Aortic dissections are twice as common in the ascending part of the aorta compared to the descending part.
It’s important to know where an aortic dissection happens, as this can impact how a person is affected, how the condition is treated, and their likelihood of survival. Tears that affect the ascending aorta are known as type A, while those that affect the descending aorta are type B.
A person’s sex also affects the type of aortic dissection they may develop, alongside their likelihood of ever developing one. For men, aortic dissection tends to happen around age 60; for women, it’s usually later, around age 65. Type A dissections are twice as likely to happen in men as in women.
Aortic dissections are primarily linked to two factors: genetic conditions and lifestyle factors that affect the heart and blood vessels. For example, poor diet and smoking may lead to hypertension (high blood pressure), which increases the likelihood of damage to the specialized cells that line the blood vessels. This makes it far more likely for a person to develop an aortic dissection.
Another significant lifestyle factor that makes a person more likely to develop an aortic dissection is cocaine use. This increases heart rate and blood pressure, while simultaneously decreasing the amount of blood passing through the arteries that supply the heart. Cocaine use not only makes a person more likely to develop an aortic dissection later in life, but it may also trigger an aortic dissection.
A number of genetic conditions are associated with an increased risk of aortic dissection too. The most common of these is a condition called Marfan syndrome, affecting about one in 5000 people. This prevents people from properly producing enough of a key protein which helps give blood vessel walls their structure and elasticity. Without enough of this protein, the blood vessel walls are weakened and at an increased risk of dissection or rupture. People with Marfan syndrome are also more likely to develop an aortic dissection at a younger age — usually around 38.
Trauma can also cause a dissection, with road traffic accidents a major cause. They can cause either a dissection to start or a spontaneous rupture of the aorta.
Possible aortic dissection treatments
Symptoms of aortic dissection include pain, described often as ripping or tearing in the chest, abdomen, or back. Where people are known to have predisposing conditions, they are monitored or medically managed, usually with drugs such as beta-blockers and antihypertensives, which reduce blood pressure and decrease risk of damage to the endothelial lining. This type of management is only really appropriate for type B dissections. Type A almost always requires immediate surgical intervention.
In people with suspected or known aortic dissection, catching it early is key. A CT scan will typically be used to diagnose the condition. Usually, the end stage of treatment is surgical repair or replacement of the defective part of the aorta. But outcomes from this procedure are mixed, with survival from surgery for a type A dissection usually around 52 to 94 percent at one year after an operation and 45 to 88 percent at five years. For type B, there’s a similar variation in survival at year 1 (around 56 to 92 percent) and at year 5 (48 percent to 82 percent).
In type B dissections, sometimes the antihypertensive medications may be used to stabilize the patient before surgery, but this is not always possible. A dissection is a serious condition and will not repair itself.
Due to the seriousness and potentially poor outcomes from aortic dissection, it’s important to modify any lifestyle factors that may contribute to an increased risk — such as exercising, eating a healthy and balanced diet, and giving up smoking. It’s also important to ensure any underlying health conditions that may put you at greater risk (such as hypertension) are medically managed.
Adam Taylor is a professor and director of the clinical anatomy learning center at Lancaster University.
This article is republished from The Conversation under a Creative Commons license. Read the original article.
